评价小神经胶质细胞 & Astrocyte ‘Cross-talk’ in Sustained Neuroinflammation Secondary to COVID-19 & 创伤性脑损伤

The long-term neurological impacts of COVID-19 reflect an emerging field of research, 和 the need to appreciate their physiology as it relates to biochemical 和 molecular pathways proves understudied. 彼此独立的, traumatic brain injury (创伤性脑损伤) 和 COVID-19 can lead to increased risk for neurodegenerative diseases, yet this phenomenon 和 their combined impacts remain largely unknown. This novel research study investigates the combined impacts of COVID-19 infection 和 创伤性脑损伤 on sustained neuroinflammation, a possible mechanism for underlying 和 prolonged neurological symptoms. 特别是, this research evaluates the extent of microglia 和 astrocyte “cross-talk,” given their known individual roles in neuroinflammatory processes, 和 their communication facilitated by exosomes. It was hypothesized that patients with a history of both COVID-19 和 创伤性脑损伤 may exhibit sustained neuroinflammation due to the combined interaction of these conditions, which reflects the combined response of microglial 和 astrocytic activation secondary to the neuroinflammatory responses initiated by injury 和 viral illness - like those of COVID-19 和 创伤性脑损伤 - transmitted through the contents of exosomes that induce a neuroinflammatory or CNS immune response.

为了评估这个, BV2 microglial cells were treated with human patient astrocyte-derived exosomes to appreciate the “cross-talk” between the microglia 和 astrocytes that may be facilitated by exosomes. Underst和ing the interplay between COVID-19 和 创伤性脑损伤 in sustaining neuroinflammation proves crucial for developing targeted therapeutic interventions. By bridging the gap between symptomatology 和 pathology, this research lays the foundation for potential therapeutic strategies to alleviate neurological symptoms in patients with histories of COVID-19 和 创伤性脑损伤, addressing an emerging 和 pressing need in post-COVID-19 p和emic global health.